제목 | Rubi-colored crops with built-in ketocarotenoid biosynthetic pathway |
---|---|
내용 |
Ketocarotenoid–biofortifed crops are required as natural additives with respect to their Rubi-like reddish color and strong
antioxidative properties for foods and feeds. They can be an alternative means of microalgal and bacterial systems and do
not depend on chemical synthesis, providing safe, sustainable, and processing-free platforms. To reach sufcient commercial
demands, diferent metabolic engineering strategies have been used in diverse crop plants. In this study, we summarized
the current achievements for de novo production of ketocarotenoids in major crops and described host crop-specifc tactics
to optimize the ketocarotenoid biosynthetic pathway, considering the following diferent levels and types of carotenoid
being accumulated as precursors: lutein and zeaxanthin in maize seeds; lutein in rice seeds, canola seeds, soybean seeds,
and tobacco fowers; zeaxanthin in potato tubers; β–carotene in carrot roots; and lycopene in tomato fruits. This study suggests prospects for the advanced performance of ketocarotenoid biofortifcation in crops in two crucial points: host crop
cultivar and the elaborately designed genetic strategies. The latter includes an increase in the total carotenoid capacity by
co-consideration to supply precursors and stabilizers, the prevention of metabolite loss in competing or catabolic pathways
or both pathways, and the sensible choice of genes and genetic elements for optimal expression. Furthermore, progresses in
synthetic biology and new biotechnology, such as genome editing, could accelerate the development of high-valued “Rubi
Crops,” which satisfy the nutritional and functional needs of humans and animals
|
첨부 |
2021 Jeong et al. a.pdf
|