제목 | Dianthiamides A–E, Proline-Containing Orbitides from Dianthus chinensis. |
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내용 |
Orbitides are plant-derived small cyclic peptides with a wide range of biological activities.
Phytochemical investigation of the whole plants of Dianthus chinensis was performed with the aim to
discover new bioactive orbitides. Five undescribed proline-containing orbitides, dianthiamides A–E
(1–5), were isolated from a methanolic extract of Dianthus chinensis. Their structures were elucidated
by extensive analysis of 1D and 2D NMR and HRESI–TOF–MS as well as ESI–MS/MS fragmentation
data. The absolute configuration of the amino acid residues of compounds 1–5 was determined by
Marfey’s method. All compounds were tested for their cytotoxic activity, and dianthiamide A (1)
exhibited weak activity against A549 cell line with IC50 value of 47.9 µM.
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첨부 |
2021 Lee et al..pdf
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